MDR1 causes resistance to the antitumour drug miltefosine
نویسندگان
چکیده
منابع مشابه
p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents.
Loss of functional p53 paradoxically results in either increased or decreased resistance to chemotherapeutic drugs. The inconsistent relationship between p53 status and drug sensitivity may reflect p53's selective regulation of genes important to cytotoxic response of chemotherapeutic agents. We reasoned that the discrepant effects of p53 on chemotherapeutic cytotoxicity is due to p53-dependent...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2001
ISSN: 1532-1827
DOI: 10.1054/bjoc.2001.1776